Tadalafil is a proven erectile dysfunction medication and its effects are cumulative and improve with daily use. It is effective for both males and females. Tadalafil orally can be effective to increase sexual desire, sexual arousal, sexual orgasm and sexual satisfaction. It not only increases nitric oxide in the corpus cavernosum of men, but in women it also results in the relaxation of clitoral and vaginal smooth muscle and increased blood flow in these sites, a normal step in arousal and necessary to achieve orgasm.

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Oxytocin certainly lives up to its reputation as the “Love Hormone”. It also has broader applications like weight management and a performance enhancer. Oxytocin levels reach extreme levels during childbirth and breastfeeding; however, they have also been found to be elevated during sexual arousal, skin-to-skin contact, and orgasm. Due to this, research has been conducted and shown that exogenous administration of Oxytocin can improve libido, orgasm intensity and frequency as well as sexual pleasure.

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Bremelanotide / (PT 141) is a very exciting drug that is frequently used by both men and women. It works on the central nervous system to directly induce an increase in libido and induces erections. It works in 80% of men who don't respond to PDE5 inhibitors (like Tadalafil) and most will now use it as a first-line therapy. The results with women are much less objective but there is far more research showing its success. It is FDA approved for women and is known to increase sexual gratifying experiences by 50%.